POMC (Human) Recombinant Protein (Q01)
产品名称： POMC (Human) Recombinant Protein (Q01)
英文名称： POMC (Human) Recombinant Protein (Q01)
产品编号： H00005443-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Human POMC partial ORF ( NP_000930, 205 a.a. - 267 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- LEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
- Theoretical MW (kDa):
- 32.67
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Publication Reference
- 1.
- Characterization of C-Kit (CD117) Expression in Human Normal Pituitary Cells and Pituitary Adenomas.
La Rosa S, Uccella S, Dainese L, Marchet S, Placidi C, Vigetti D, Capella C.Endocr Pathol. 2008 Summer;19(2):104-11.
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 5443
- GeneBank Accession#:
- NM_000939
- Protein Accession#:
- NP_000930
- Gene Name:
- POMC
- Gene Alias:
- ACTH,CLIP,LPH,MSH,NPP,POC
- Gene Description:
- proopiomelanocortin
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000119991,adrenocorticotropic hormone,adrenocorticotropin,alpha-MSH,alpha-melanocyte-stimulating hormone,beta-LPH,beta-MSH,beta-endorphin,beta-melanocyte-stimulating hormone,corticotropin-like intermediary peptide,gamma-LPH,gamma-MSH,lipotropin b
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