ABCG8 polyclonal antibody
产品名称： ABCG8 polyclonal antibody
英文名称： ABCG8 polyclonal antibody
产品编号： PAB12502
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ABCG8.
- Immunogen:
- A synthetic peptide corresponding to N-terminus of human ABCG8.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody is specific to human ABCG8.
- Form:
- Liquid
- Storage Buffer:
- In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1:250)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid.
Mathur SN, Watt KR, Field FJ.J Lipid Res. 2007 Feb;48(2):395-404. Epub 2006 Nov 18.
- 2.
- Role of ABCG1 and other ABCG family members in lipid metabolism.
Schmitz G, Langmann T, Heimerl S.J Lipid Res. 2001 Oct;42(10):1513-20.
- 3.
- Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.
Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, Kojima H, Ose L, Stalenhoef AF, Mietinnen T, Bjorkhem I, Bruckert E, Pandya A, Brewer HB Jr, Salen G, Dean M, Srivastava A, Patel SB.Am J Hum Genet. 2001 Aug;69(2):278-90. Epub 2001 Jul 9.
- 4.
- Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.
Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, Calandra S, Bertolini S, Cossu F, Grishin N, Barnes R, Cohen JC, Hobbs HH.Science. 2001 May 18;292(5520):1394-8. Epub 2001 Apr 26.
- Application Image
- Western Blot
- Entrez GeneID:
- 64241
- Protein Accession#:
- Q9H221
- Gene Name:
- ABCG8
- Gene Alias:
- GBD4,MGC142217,STSL
- Gene Description:
- ATP-binding cassette, sub-family G (WHITE), member 8
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq
- Other Designations:
- ATP-binding cassette sub-family G member 8,ATP-binding cassette, subfamily G, member 8,sterolin 2
- Gene Pathway
- Related Disease
- Atherosclerosis
- Atherosclerosis
- Biliary Tract Neoplasms
- Cardiovascular Diseases
- Cholelithiasis
- Coronary Artery Disease
- Coronary Disease
- Diseases in Twins
- Dyslipidemias
- Gallbladder Neoplasms
- Gallstones
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Hyperlipidemias
- Hyperlipoproteinemia Type II
- Insulin Resistance
- Kidney Failure, Chronic
- Lung Neoplasms
- Metabolic Syndrome X