BRCA1 monoclonal antibody, clone RAY
产品名称： BRCA1 monoclonal antibody, clone RAY
英文名称： BRCA1 monoclonal antibody, clone RAY
产品编号： MAB2362
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant BRCA1.
- Immunogen:
- Recombinant protein corresponding to amino acids 1314-1864 of human BRCA1.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes the epitope aa 1314-1600.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Immunocytochemistry (1:100)
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
Aglipay JA, Lee SW, Okada S, Fujiuchi N, Ohtsuka T, Kwak JC, Wang Y, Johnstone RW, Deng C, Qin J, Ouchi T.Oncogene. 2003 Dec 4;22(55):8931-8.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of BRCA1 in MCF-7 whole cell lysate using BRCA1 monoclonal antibody, clone RAY (Cat # MAB2362). 1 minute ECL Western blot analysis.
- Entrez GeneID:
- 672
- Protein Accession#:
- P38398
- Gene Name:
- BRCA1
- Gene Alias:
- BRCAI,BRCC1,IRIS,PSCP,RNF53
- Gene Description:
- breast cancer 1, early onset
- Omim ID:
- 113705
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq
- Other Designations:
- BRCA1/BRCA2-containing complex, subunit 1,breast and ovarian cancer susceptibility protein 1
- Gene Pathway
- Related Disease
- Abdominal Neoplasms
- Abortion, Habitual
- Abortion, Spontaneous
- Adenocarcinoma
- Adenocarcinoma, Clear Cell
- Adenocarcinoma, Mucinous
- Adenoma, Pleomorphic
- Anticipation, Genetic
- Anxiety Disorders
- Ataxia Telangiectasia
- Ataxia telangiectasia
- Awareness
- Bloom Syndrome
- Body Image
- Body Weight
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Breast Neoplasms, Male