GAB2 polyclonal antibody
产品名称： GAB2 polyclonal antibody
英文名称： GAB2 polyclonal antibody
产品编号： PAB7265
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of GAB2.
- Immunogen:
- A synthetic peptide corresponding to human GAB2.
- Sequence:
- C-QVDKEKTQALQN
- Host:
- Goat
- Theoretical MW (kDa):
- 74.5, 70
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_536739.1, NP_0.36428.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:64000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A role for the scaffolding adapter GAB2 in breast cancer.
Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H.Nat Med. 2006 Jan;12(1):114-21. Epub 2005 Dec 20.
- Entrez GeneID:
- 9846
- Protein Accession#:
- NP_536739.1;NP_0.36428.1
- Gene Name:
- GAB2
- Gene Alias:
- KIAA0571
- Gene Description:
- GRB2-associated binding protein 2
- Omim ID:
- 606203
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- Grb2-associated binder 2