Uniprot ID:P04664
Gene Names:HA
Source:E.coli
Tag Info:His-SUMO-tag
Expression Region:1-328aa
MW:52.05kD
Sequence Info:Full length
Alternative name(s):Cleaved into the following chain:
Hemagglutinin HA1 chain
relevance:Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
reference:"Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity."
Sleigh M.J., Both G.W., Underwood P.A., Bender V.J.
J. Virol. 37:845-853(1981)
Purity:Greater than 90% as determined by SDS-PAGE.
Storage Buffer:20mM Tris-HCl based buffer,pH8.0
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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