Anti-Smad2 Monoclonal Antibody  

品牌：solarbio | 货号：K000096M

英文名称	Anti-Smad2 Monoclonal Antibody
宿主	Mouse
别名	hMAD-2;hSMAD2;JV18;JV18-1;MADH2;MADR2
应用	WB ICC
稀释比例	WB 1:500. ICC 1:100.
交叉反应	Human
蛋白分子量	60kDa
Gene ID	4087
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human Smad2 protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human Smad2 protein fragments expressed in E.coli.
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q15796
克隆号	6H5-E3-C11
克隆类型	Monoclonal Antibody
背景资料	The protein encoded by this gene belongs to the SMAD,a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.This protein mediates the signal of the transforming growth factor (TGF)-beta,and thus regulates multiple cellular processes,such as cell proliferation,apoptosis,and differentiation.This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein.In response to TGF-beta signal,this protein is phosphorylated by the TGF-beta receptors.The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4.The association with SMAD4 is important for the translocation of this protein into the nucleus,where it binds to target promoters and forms a transcription repressor complex with other cofactors.This protein can also be phosphorylated by activin type 1 receptor kinase,and mediates the signal from the activin.Alternatively spliced transcript variants have been observed for this gene.[provided by RefSeq,May 2012]