FITC标记的UBX结构域域蛋白D2抗体
产品名称： FITC标记的UBX结构域域蛋白D2抗体
英文名称： Anti-UBXD2/FITC
产品编号： HZ-11675R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-UBXD2/FITC Conjugated antibody
FITC标记的UBX结构域域蛋白D2抗体
| 产品编号 | bs-11675R-FITC |
| 英文名称 | Anti-UBXD2/FITC |
| 中文名称 | FITC标记的UBX结构域域蛋白D2抗体 |
| 别 名 | Erasin; FLJ23318; KIAA0242; KIAA2042; UBX domain containing 1; UBX domain containing 2; UBX domain containing protein 2; UBXD 2; UBXDC 1; UBXDC1; UBXN4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBXD2 (201-300aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease. Function: UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP) and promotes ER-associated protein degradation (ERAD). Immunohistochemical staining of brain tissue from patients with Alzheimer's disease and control subjects revealed that UBXD2 accumulates preferentially in neurons undergoing neurofibrillary degeneration in Alzheimer's disease. Subunit: Directly interacts with VCP. Subcellular Location: Endoplasmic reticulum membrane. Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER. Tissue Specificity: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level). Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 UBX domain. Database links: Entrez Gene: 476130 Dog Entrez Gene: 23190 Human Entrez Gene: 67812 Mouse Entrez Gene: 304766 Rat Omim: 611216 Human SwissProt: Q92575 Human SwissProt: Q8VCH8 Mouse SwissProt: Q5HZY0 Rat Unigene: 709238 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Erasin是内质网（ER）和核膜膜蛋白。在多种组织中，如脑、胎盘、心脏、肝脏、前列腺、肾脏、胰腺、肺和骨骼肌中，Erasin含有一个UBX结构域，参与Erad（内质网相关蛋白降解）底物的清除。Erasin结构域负责介导其与VCP（含Valasin的蛋白质）的直接相互作用，AAA ATPase分子伴侣。在ER应激下，诱导了Erasin的表达。Erasin表达的敲除导致Erad的抑制，提示Erasin在Erad通路中的重要作用。此外，Erasin可能参与阿尔茨海默病，因为它已知在阿尔茨海默病患者的神经纤维变性神经元中积累。