PTPN6 monoclonal antibody, clone 10F5
产品名称： PTPN6 monoclonal antibody, clone 10F5
英文名称： PTPN6 monoclonal antibody, clone 10F5
产品编号： MAB0815
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant PTPN6.
- Immunogen:
- Recombinant His/ABD fusion protein corresponding to amino acids 391-595 of human PTPN6.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling.
Honorat JF, Ragab A, Lamant L, Delsol G, Ragab-Thomas J.Blood. 2006 May 15;107(10):4130-8. Epub 2006 Feb 9.
- 2.
- The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.
Neel BG, Gu H, Pao L.Trends Biochem Sci. 2003 Jun;28(6):284-93.
- 3.
- The function of the protein tyrosine phosphatase SHP-1 in cancer.
Wu C, Sun M, Liu L, Zhou GW.Gene. 2003 Mar 13;306:1-12.
- Entrez GeneID:
- 5777
- Gene Name:
- PTPN6
- Gene Alias:
- HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 6
- Omim ID:
- 176883
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
- Other Designations:
- hematopoietic cell phosphatase,hematopoietic cell protein-tyrosine phosphatase,protein-tyrosine phosphatase 1C