1) Cat. No.: TRC-E588980; 2) Chemical Name: Epothilone A; 3) CAS No.: 152044-53-6; 4) Mol. Formula: C26H39NO6S; 5) Mol. Weight: 493.66; 6) Packing Size: 0.1mg / 1mg; 7) Appearence: ; 8) Application Notes: The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.; 9) Synonym: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (-)-Epothilone A; Epothilone A;; 10) Solubility: ; 11) Storage condition: ; 12) References: Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)