AKT2 polyclonal antibody
产品名称： AKT2 polyclonal antibody
英文名称： AKT2 polyclonal antibody
产品编号： PAB18079
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AKT2.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S474 of human AKT2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to AKT2.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500~1:1000)
Immunohistochemistry (1:50~1:100)
ELISA(1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.
Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ.Cancer Res. 2001 Aug 15;61(16):5985-91.
- 2.
- Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer.
Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ.Oncogene. 2000 May 4;19(19):2324-30.
- 3.
- Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA.J Biol Chem. 1997 Nov 28;272(48):30491-7.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from A2780 (Lane 1), 293 (Lane 2) and LOX (Lane 3 and lane 4) using AKT2 polyclonal antibody (Cat # PAB18079).
Peptide "+" means "with peptide blocking".
- Entrez GeneID:
- 208
- Protein Accession#:
- P31751
- Gene Name:
- AKT2
- Gene Alias:
- PKBB,PKBBETA,PRKBB,RAC-BETA
- Gene Description:
- v-akt murine thymoma viral oncogene homolog 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq
- Other Designations:
- Murine thymoma viral (v-akt) homolog-2,rac protein kinase beta
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Glioma
- Insulin signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- mTOR signaling pathway
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Renal cell carcinoma
- Small cell lung cancer
- T cell receptor signaling pathway
- Tight junction
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Drug Toxicity
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- HIV Infections
- Hypercholesterolemia
- Insulin Resistance
- Lipodystrophy
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasms, Glandular and Epithelial
- Ovarian cancer
- Ovarian Neoplasms