FITC标记的微管蛋白γ/Tubulin γ抗体
产品名称： FITC标记的微管蛋白γ/Tubulin γ抗体
英文名称： Anti-gamma tubulin/FITC
产品编号： HZ-1322R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-gamma tubulin/FITC Conjugated antibody
FITC标记的微管蛋白γ/Tubulin γ抗体
| 英文名称 | Anti-gamma tubulin/FITC |
| 中文名称 | FITC标记的微管蛋白γ/Tubulin γ抗体 |
| 别 名 | Centrosome Marker; Gamma 1 tubulin; gamma tubulin; gamma-tubulin; Gamma 2 tubulin; Gamma Tubulin 1; Gamma Tubulin 2; Gamma tubulin complex component 1; GCP 1; GCP-1; GCP1; MGC131994; TUBG; TUBG1; TUBG2; Tubulin gamma 1 chain; Tubulin gamma 2 chain; Xgam; TBG1_HUMAN; TBG2_HUMAN; Tubulin gamma-1 chain; Gamma-1-tubulin; Gamma-tubulin complex component 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tubulin gamma-1 chain |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Centrosome Marker Gamma tubulin, a member of the tubulin superfamily, is a ubiquitous and highly conserved protein within the microtubule organizing centre (MTOC). Gamma tubulin is not a component of microtubules, rather it functions as the microtubule nucleator at the MOTC, is responsible for binding microtubule minus ends and mediating the link between microtubles and the centrosome. By binding to the beta tubulin subunit of the tubulin molecule, it establishes the polarity of a microtubule leaving the alpha tubulin subunit exposed at the positive end. The abundance of Gamma tubulin is less than 1% of the level of either alpha or beta tubulin. It shares approximately 28-32% identity with alpha tubulin from various organisms and 32-36% identity with beta tubulins. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis and the microtubule cytoskeleton. Function: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Subunit: Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Post-translational modifications: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome. Similarity: Belongs to the tubulin family. Database links: Entrez Gene: 27175 Human Entrez Gene: 7283 Human Entrez Gene: 103733 Mouse Entrez Gene: 103768 Mouse Entrez Gene: 252921 Rat Entrez Gene: 680991 Rat Omim: 191135 Human Omim: 605785 Human SwissProt: P23258 Human SwissProt: Q9NRH3 Human SwissProt: P83887 Mouse SwissProt: Q8VCK3 Mouse SwissProt: P83888 Rat Unigene: 279669 Human Unigene: 708059 Human Unigene: 142348 Mouse Unigene: 479145 Mouse Unigene: 154431 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 结构蛋白（Structural Proteins） gamma tubulin 微管蛋白是存于中心体的另一种微管蛋白, gamma微管蛋白对微管的形成具有重要作用。gamma微管蛋白通过与β-微管蛋白的相互作用帮助微管的成核反应(nucleation)。即在微管的组装中gamma微管蛋白先形成一个圆或形成钩环结构, γ微管蛋白的这种结构可指导微管蛋白二聚体结合上去并进行微管的组装。gamma微管蛋白在微管的组装中起关键作用 |
微管蛋白微管蛋白是微管组织中心（MTOC）中的一种普遍存在且高度保守的蛋白。γ-微管蛋白不是微管的一个组成部分，而是作为MOTC中的微管成核剂发挥作用，负责微管负末端的结合，并介导微管与中心体之间的联系。通过结合微管蛋白分子的β-微管蛋白亚基，它建立了微管的极性，使位于正端的α-微管蛋白亚基暴露出来。
γ-微管蛋白的丰度小于α或β微管蛋白水平的1%。它与来自不同生物体的α-微管蛋白的同源性约为23-32%，与β-微管蛋白的同源性为32-36%。涉及微管功能的蛋白质的检测、定位和鉴定是理解有丝分裂、减数分裂和微管细胞骨架的基础。