PLA2G4A polyclonal antibody
产品名称: PLA2G4A polyclonal antibody
英文名称: PLA2G4A polyclonal antibody
产品编号: PAB18118
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PLA2G4A.
- Immunogen:
- A synthetic peptide corresponding to human PLA2G4A.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to PLA2G4A.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments.
Kolko M, Wang J, Zhan C, Poulsen KA, Prause JU, Nissen MH, Heegaard S, Bazan NG.Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1401-9.
- 2.
- An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles.
Duffy DM, Seachord CL, Dozier BL.J Clin Endocrinol Metab. 2005 Oct;90(10):5858-65. Epub 2005 Jun 21.
- 3.
- Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway.
Denson DD, Li J, Wang X, Eaton DC.J Neurophysiol. 2005 Jun;93(6):3146-56. Epub 2005 Jan 12.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HeLa cells, treated with TNF-a (20 ng/mL, 30 mins), using PLA2G4A polyclonal antibody (Cat # PAB18118).
Peptide "+" means "peptide blocking".
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PLA2G4A polyclonal antibody (Cat # PAB18118).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 5321
- Protein Accession#:
- P47712
- Gene Name:
- PLA2G4A
- Gene Alias:
- MGC126350,PLA2G4,cPLA2-alpha
- Gene Description:
- phospholipase A2, group IVA (cytosolic, calcium-dependent)
- Omim ID:
- 600522
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq
- Other Designations:
- OTTHUMP00000033543,calcium-dependent phospholipid-binding protein,cytosolic phospholipase A2, group IVA,lysophospholipase,phosphatidylcholine 2-acylhydrolase
- Gene Pathway
- alpha-Linolenic acid metabolism
- Arachidonic acid metabolism
- Ether lipid metabolism
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glycerophospholipid metabolism
- GnRH signaling pathway
- Linoleic acid metabolism
- Long-term depression
- MAPK signaling pathway
- Metabolic pathways
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Related Disease
- Adenomatous Polyposis Coli
- Alzheimer Disease
- Alzheimer disease
- Asthma
- Asthma
- Bipolar Disorder
- Cardiovascular Diseases
- Connective Tissue Diseases
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Ductus Arteriosus, Patent
- Edema
- Fetal Diseases
- Genetic Predisposition to Disease
- Hepatitis C, Chronic
- HIV Infections
- Hyperinsulinism
- Infant, Premature, Diseases
- Infection