DUSP10 (C-term) Peptide
产品名称： DUSP10 (C-term) Peptide
英文名称： DUSP10 (C-term) Peptide
产品编号： P3286
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP10.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DUSP10.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A.Oncogene. 1999 Nov 25;18(50):6981-8.
- 2.
- Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
Tanoue T, Moriguchi T, Nishida E.J Biol Chem. 1999 Jul 9;274(28):19949-56.
- 3.
- The "VH1-like" dual-specificity protein tyrosine phosphatases.
Martell KJ, Angelotti T, Ullrich A.Mol Cells. 1998 Feb 28;8(1):2-11.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of DUSP10 polyclonal antibody (Cat # PAB4137) in CEM cell lysate (35 ug/lane). DUSP10 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with DUSP10 polyclonal antibody (Cat # PAB4137) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 11221
- Protein Accession#:
- NP_009138;Q9Y6W6
- Gene Name:
- DUSP10
- Gene Alias:
- MKP-5,MKP5
- Gene Description:
- dual specificity phosphatase 10
- Omim ID:
- 608867
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000035380,dual specificity phosphatase MKP-5,map kinase phosphatase 5,serine/threonine specific protein phosphatase
- Gene Pathway
- Related Disease