http://www.creativebiomart.net/description_382866_12.htm

CD70, also known as CD27 ligand (CD70 / CD27L / TNFSF7), is a member of the tumor necrosis factor superfamily (ie. TNFSF7) and a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. CD70 is a single-pass type Ⅲ transmebrane glycoprotin consisting of a short cytoplasmic domain (1-17aa) , a transmembrane domain (18-38 aa) and a 155aa extracellular domain (39-193), and exists as a homotrimer in vivo. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 expression on malignant cells coupled with its highly restricted expression on normal cells makes CD70 an attractive target for monoclonal antibody -based therapies.