MCL1 polyclonal antibody
产品名称： MCL1 polyclonal antibody
英文名称： MCL1 polyclonal antibody
产品编号： PAB8824
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MCL1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding amino acids 131 of human MCL1.
- Host:
- Rabbit
- Reactivity:
- Cat, Dog, Human, Monkey, Mouse, Pig, Rabbit, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal)
- Storage Instruction:
- Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.5-4 ug/mL)
Immunoprecipitation (10-20 ug/mL)
Immunohistochemistry (10-20 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells.
Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, Lin Y.Mol Cancer Ther. 2008 May;7(5):1156-63.
- Entrez GeneID:
- 4170
- Gene Name:
- MCL1
- Gene Alias:
- BCL2L3,EAT,MCL1L,MCL1S,MGC104264,MGC1839,TM
- Gene Description:
- myeloid cell leukemia sequence 1 (BCL2-related)
- Omim ID:
- 159552
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq
- Other Designations:
- OTTHUMP00000032794,OTTHUMP00000032795,induced myeloid leukemia cell differentiation protein Mcl-1,myeloid cell leukemia sequence 1,myeloid cell leukemia sequence 1, isoform 1