1) Cat. No.: TRC-L486500; 2) Chemical Name: LY 2228820; 3) CAS No.: 862507-23-1; 4) Mol. Formula: C26H37FN6O6S2; 5) Mol. Weight: 612.74; 6) Packing Size: 5mg / 50mg; 7) Appearence: ; 8) Application Notes: LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.; 9) Synonym: 5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009); Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2008); Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2008);